I have experience in much of the CMS mentioned.

I have done numbers of site with phpnuke, it's true that there are numbers of disadvantages about it. The only major disadvantages I would like to highlight is the security, other than that, everything is fine. It can has user friendly URL, you can find tonnes of add-on, getting great supports as many people are using it (this may also be the reason for more security issue).

Drupal is really a nice CMS, I can really recommend it, it's strong, powerful, nice security. Just that you might take some times to go through it.

You might also look into e107, a nice CMS with lot's of build in features. More easy for upgrade work.

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aLvinHan of ViNSiGN Web Design in Labuan and PJ