WP2.2 is problem free in my case. Though I don't see much changes in my POV as a normal user.
The most notable change in WP2.2 is the ability to change the URL without changing the value in your database, which is good when you want to do some local environment testing, while having your database sync to your realtime online blog. Oh, not forgeting the intergration of widgets engine, which I think is pretty useless for users like me since I like to get my hands dirty playing around with the theme files.
